Terlipressin Acetate - An Exceptional API Solution

Product Overview

Chemical & Physical Properties

Terlipressin Acetate, with the CAS number 14636 - 12 - 5, is a highly valuable active pharmaceutical ingredient (API) in the medical field. Its chemical name is triglycyl-lysine vasopressin acetate. As a synthetic long-acting vasopressin preparation, it plays a crucial role in the treatment of various diseases.

Properties

This product appears as a white or off-white loose block or powder, and it is hygroscopic. Terlipressin Acetate exhibits excellent solubility in water and 1% acetic acid solution. This characteristic provides great convenience for formulation and processing during pharmaceutical production, ensuring precise preparation of various dosage forms to meet diverse clinical application requirements.

Product Highlights

Unique Mechanism of Action - Long-lasting and Stable Efficacy Release

Terlipressin Acetate is a prodrug that is inactive by itself. After entering the human body, through the action of aminopeptidase, it slowly removes the three glycyl residues at the N-terminus, continuously releasing active lysine vasopressin. Thanks to this unique "slow-release" mechanism, a single administration can maintain smooth muscle contraction for up to 10 hours. In contrast, the activity of the same dose of ordinary vasopressin can only last for 20 - 40 minutes. With its long-lasting and stable efficacy release, Terlipressin Acetate can reduce the frequency of administration in clinical treatment, improve patient compliance, and ensure the continuity and stability of therapeutic effects, providing patients with a more reliable treatment experience.

Wide Clinical Applications - Therapeutic Potential in Multiple Fields

1. Esophageal Variceal Bleeding: It is currently the only drug that can improve the survival rate of patients with esophageal variceal bleeding. By contracting the smooth muscles of the visceral blood vessels, it effectively reduces visceral blood flow, thereby decreasing portal venous blood flow and pressure, fundamentally alleviating bleeding symptoms, buying precious rescue time for patients, and significantly improving the prognosis of patients.

2.        Hepatorenal Syndrome: It can reduce plasma renin concentration, increase renal blood flow in patients with hepatorenal syndrome, effectively improve renal function, and increase urine output, which is of great significance for improving the liver and kidney conditions of patients and delaying disease progression.

3.        Other Fields: Terlipressin Acetate is also likely to play a beneficial role in refractory shock and cardiopulmonary resuscitation, demonstrating its therapeutic potential in multiple fields and providing new possibilities for the treatment of more complex diseases.

High Safety and Reliability - A Trustworthy Choice for Clinical Use

Due to the slow enzymatic hydrolysis rate, lysine vasopressin will not reach toxic levels during circulation. Compared with traditional vasopressin, Terlipressin Acetate has a longer-lasting effect and does not cause serious complications such as fibrinolytic promotion and cardiovascular problems. It has a simple and convenient administration method via intravenous injection, making it especially suitable for the emergency rescue and treatment of critically ill patients. Our strict production standards and quality control system ensure the stable and reliable quality of each batch of products, providing medical professionals and patients with a highly safe and trustworthy treatment option.

Quality Assurance

We are equipped with advanced production facilities and a production process that strictly adheres to cGMP standards. Every step, from raw material procurement to finished product delivery, is strictly controlled and tested. The product purity, detected by high-performance liquid chromatography (HPLC), consistently meets the high standard of ≥95%, conforming to various international quality specifications, and providing a solid guarantee for your production needs.

Application Areas

Primarily applied in the pharmaceutical industry, it is used for the production of injectable drugs for the treatment of diseases such as esophageal variceal bleeding, hepatorenal syndrome, and refractory shock.

Storage Conditions

Please store the product at 4°C, keep it sealed, and avoid moisture and light exposure to ensure the long-term stability of product quality.

Should you have any inquiries or requirements regarding Terlipressin Acetate API, please feel free to contact us. Our professional team is dedicated to serving you and looks forward to collaborating with you to create a brighter future in the pharmaceutical field.